منابع مشابه
RNA and dynamic nuclear organization: Long noncoding RNAs may function as organizing factors that shape the cell nucleus
John Rinn1,2,3 and Mitchell Guttman4 John Rinn: [email protected]; Mitchell Guttman: [email protected] 1Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA 2Beth Israel Deaconess Medical Center, Boston, MA 02215, USA 3Broad Institute of MIT and Harvard, Cambridge, MA 02138, USA 4Division of Biology and Biological Engineering, California Institute of Techno...
متن کاملThe dynamic organization of gene-regulatory machinery in nuclear microenvironments.
Nuclear components are functionally linked with the dynamic temporal and spatial compartmentalization, sorting and integration of regulatory information to facilitate its selective use. For example, the subnuclear targeting of transcription factors to punctate sites in the interphase nucleus mechanistically couples chromatin remodelling and the execution of signalling cascades that mediate gene...
متن کاملRCC1 and nuclear organization.
We have examined the effect of RCC1 function on the nuclear organization of pre-mRNA splicing factors and poly(A)+ RNA in the tsBN2 cells, a RCC1 temperature-sensitive mutant cell line. We have found that at 4-6 h after shifting cells from the permissive temperature (32.5 degrees C) to the restrictive temperature (39.5 degrees C), both small nuclear ribonucleoprotein particles and a general spl...
متن کاملNuclear organization and chromosome segregation.
The genetic information underlying plant form and function is contained within the cell nucleus in the form of complex, dynamic DNA–protein structures—the chromosomes. The faithful transmission of these structures during mitosis and meiosis requires extensive chromosome reorganization and the formation of a unique, transient structure, the spindle, which serves to segregate chromosomes to daugh...
متن کاملNuclear organization and genome function.
Long-range interactions between transcription regulatory elements play an important role in gene activation, epigenetic silencing, and chromatin organization. Transcriptional activation or repression of developmentally regulated genes is often accomplished through tissue-specific chromatin architecture and dynamic localization between active transcription factories and repressive Polycomb bodie...
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ژورنال
عنوان ژورنال: Science
سال: 2014
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.1252966